Inter-agency collaboration is paramount to the protection of vulnerable children, especially in families with a complex array of problems. This article presents a range of recommendations to improve collaboration between child protection workers and mental health/drug and alcohol clinicians - from the perspective of clinicians operating in Keep Them Safe-Whole Family Team (KTS-WFT), a New South Wales referral service providing interventions to families with parental mental health/drug and alcohol problems where there are child protection concerns. Participants reported a number of barriers to effective collaboration and recommended options for how these could be addressed.